ACTH deficiency

The presentation of this deficiency can be life threatening if not treated in time. 

ACTH deficiency is one form of hypopituitarism.  The condition is also called secondary adrenal insufficiency, has two major differences from from primary adrenal insufficiency. One difference is that there is no salt wasting in this condition and the other differences is there is no resultant hyperpigmentation (darkening of the skin creases).  Otherwise, the symptoms of both forms of adrenal insufficiency are similar.

The symptoms and signs of this condition range from none to severe. These include low blood sodium levels, fatigue, weight loss, loss of appetite, decreased libido, high blood eosinophil counts, posture-dependent low blood pressure, fast heart rates, and death due to vascular collapse.

A related condition is primary adrenal insufficiency. This is a condition where the adrenal glands themselves do not produce enough cortisol. The symptoms are the same as ACTH deficiency and can be life threatening.